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CD30‐positive primary cutaneous anaplastic large cell lymphoma with coexistent pseudocarcinomatous hyperplasia
Author(s) -
Kreuter A.,
Pantelaki I.,
Michalowitz A.L.,
Wieland U.,
Cerroni L.,
Oellig F.,
Tigges C.
Publication year - 2018
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/ced.13416
Subject(s) - cd30 , anaplastic large cell lymphoma , lymphoma , pathology , medicine , lymphoproliferative disorders , lymphomatoid papulosis , large cell , scalp , hyperplasia , mycosis fungoides , dermatology , cancer , adenocarcinoma
Summary CD30‐positive primary cutaneous anaplastic large cell lymphoma (C‐ALCL) is an indolent type of cutaneous lymphoma with favourable clinical prognosis. Pseudocarcinomatous hyperplasia (PCH) is a rare benign epithelial condition that can resemble invasive squamous cell carcinoma both clinically and histopathologically. PCH predominantly occurs in CD30‐positive lymphoproliferative disorders. We report a 75‐year‐old woman with PCH in a multifocal C‐ALCL located on the scalp and right retroauricular area, which rapidly responded to treatment with psoralen ultraviolet A photochemotherapy. Comprehensive virological analyses for potential oncogenic viruses, including Epstein–Barr virus, human herpesvirus‐8, human papillomaviruses, the recently discovered cutavirus and nine different human polyomaviruses, were negative.