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Plasmacytoid dendritic cells and type I interferon in the immunological response against warts
Author(s) -
Saadeh D.,
Kurban M.,
Abbas O.
Publication year - 2017
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/ced.13187
Subject(s) - epidermodysplasia verruciformis , pathogenesis , papilloma , immunology , interferon , medicine , interferon type i , immune system , virus , pathology
Summary Background Plasmacytoid dendritic cells ( pDC s) are the most potent producers of type I interferons ( IFN s), and are involved in the pathogenesis of several cutaneous infectious (especially viral), inflammatory/autoimmune and neoplastic entities. Their role in the pathogenesis and regression of human papilloma virus ( HPV )‐induced skin lesions has not been well studied. Aim To investigate pDC occurrence and activity in HPV ‐induced skin lesions, including inflamed and uninflamed warts as well as epidermodysplasia verruciformis ( EDV )‐associated lesions. Methods In total 20 inflamed and 20 uninflamed HPV ‐induced skin lesions (including 7 EDV lesions) were retrieved from our database, and the tissue was immunohistochemically tested for pDC occurrence and activity using anti‐ BDCA ‐2 and anti‐MxA antibodies, respectively. Results pDC s were present in all 20 inflamed warts and absent from all 20 uninflamed cases. MxA expression was also diffuse and strong in 75% (15/20) inflamed warts, but not in any of the uninflamed warts. Conclusions pDC s constitute a central component of the inflammatory host response in inflamed warts, possibly contributing to their regression through production of type I interferons.