Premium
Comprehensive profiling of H‐Ras signalling in angiosarcoma endothelium
Author(s) -
Costa A.,
Bonner M.,
Arbiser J. L.
Publication year - 2017
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/ced.13149
Subject(s) - angiosarcoma , profiling (computer programming) , signalling , medicine , endothelium , cancer research , pathology , biology , microbiology and biotechnology , computer science , operating system
Summary The MS 1/ SVR system, in which MS 1 represents immortalized endothelial cells and SVR represents MS 1 cells transformed with oncogenic human–rat sarcoma protein (H‐Ras), has been used for around 20 years as a valuable tool to study angiogenesis and carcinogenesis. Despite the use of these cells in numerous studies, a comprehensive profile of the signalling differences due to oncogenic H‐Ras transformation has not been performed previously. In this study, we profiled the well‐known MS 1 and SVR cell lines using a combination of both Western blot and gene chip assays.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom