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Skin involvement as the first symptom of rapidly progressive ALK ‐positive systemic anaplastic large cell lymphoma
Author(s) -
Yu X.,
Zhang J.,
Xu K.,
Li M.,
Yao Z.
Publication year - 2017
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/ced.13146
Subject(s) - anaplastic lymphoma kinase , anaplastic large cell lymphoma , medicine , lymphoma , cd30 , pathology , large cell , dermatology , large cell lymphoma , lymph , cancer , adenocarcinoma , malignant pleural effusion , lung cancer
Summary Systemic anaplastic large cell lymphomas (sALCLs) comprise a heterogeneous group of relatively rare T‐cell non‐Hodgkin lymphomas that are characterized by CD30 expression. Anaplastic lymphoma kinase (ALK)‐positive ALCL is a type of sALCL that commonly involves lymph nodes and extranodal sites. Skin involvement usually presents as tumours, nodules and ulcers. We describe an unusual case of ALK‐positive ALCL in an 11‐year‐old Chinese boy, who initially presented with skin eruption with rapid progression and poor prognosis. This case emphasizes the value of clinical factors to predict the prognosis of ALK‐positive sALCL, and we recommend close collaboration between dermatologists, pathologists and haematologists/oncologists to assure the correct diagnosis and treatment.