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Relapsing bullous amyloidosis of the oral mucosa and acquired cutis laxa in a patient with multiple myeloma: a rare triple association
Author(s) -
GonzalezRamos J.,
GarridoGutiérrez C.,
GonzálezSilva Y.,
YébenesGregorio L.,
Beato Merino M.,
VidaurrázagaArcaya C.,
HerranzPinto P.
Publication year - 2017
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/ced.13084
Subject(s) - cutis laxa , plasma cell dyscrasia , medicine , dyscrasia , multiple myeloma , amyloidosis , pathology , macroglossia , dermatology , oral mucosa , al amyloidosis , plasma cell , immunoglobulin light chain , immunology , tongue , antibody
Summary It is well known that primary systemic amyloidosis [light chain ( AL ) amyloidosis] is associated with hidden dyscrasia or multiple myeloma. Acquired cutis laxa (cutis laxa acquisita; CLA ) has also been described in patients with plasma cell dyscrasias, including multiple myeloma. We report a case in which haemorrhagic oral bullae were the first sign of an undiagnosed primary systemic amyloidosis related to multiple myeloma IgG‐λ and previously diagnosed CLA . There is only one report in literature of this rare triple association; however, in that case the patient did not have oral mucosal involvement or bullous amyloidosis.