Premium
Diagnostic accuracy of reflectance confocal microscopy using VivaScope for detecting and monitoring skin lesions: a systematic review
Author(s) -
Edwards S. J.,
OseiAssibey G.,
Patalay R.,
Wakefield V.,
Karner C.
Publication year - 2017
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/ced.13055
Subject(s) - medicine , lentigo maligna , diagnostic accuracy , dermatology , basal cell carcinoma , lentigo maligna melanoma , melanoma , skin cancer , biopsy , pathology , dermatoscopy , histopathology , radiology , cochrane library , basal cell , cancer , meta analysis , cancer research
Summary Background Skin cancer is one of the most common cancers in the UK . Patients with suspicious skin lesions are assessed clinically with/without dermoscopy, and lesions still considered suspicious are then surgically removed or have the diagnosis confirmed by a punch biopsy. Aim To evaluate the diagnostic accuracy of the in vivo VivaScope © reflective confocal microscopy ( RCM ) system, a noninvasive technology designed to provide a more accurate presurgical diagnosis, leading to fewer biopsies of benign lesions, or to provide greater accuracy for lesion margins. Methods MEDLINE , EMBASE and the Cochrane Library were searched to identify studies evaluating dermoscopy plus RCM , or RCM alone, with histopathology as the reference test. Clinical experts were also contacted for information on unpublished studies. Results Eleven studies met the inclusion criteria but were too heterogeneous to be combined by meta‐analysis. Results indicated that VivaScope subsequent to dermoscopy may improve diagnostic accuracy of malignant melanomas compared with dermoscopy. For margin delineation, the data suggest that mapping using VivaScope 1500 for lentigo maligna ( LM ) and LM melanoma may improve accuracy in terms of complete excision of lesions compared with dermoscopically determined margins. For basal cell carcinoma, the limited data show high diagnostic accuracy with both VivaScope 1500 and VivaScope 3000. Evidence on the effectiveness of VivaScope in diagnosing cutaneous squamous cell carcinomas was very limited. Conclusion The use of VivaScope 1500 following dermoscopy may improve patient care and management of suspicious skin lesions, although the generalizability of these results to the UK population remains unclear.