Piperacillin–tazobactam‐induced linear IgA bullous dermatosis presenting clinically as Stevens–Johnson syndrome/toxic epidermal necrolysis overlap

Summary Linear IgA bullous dermatosis ( LABD ) is a subepidermal autoimmune bullous disease characterized by linear IgA deposition at the basement membrane zone, which is visualized by direct immunofluorescence. Patients with LABD typically present with widespread vesicles and bullae; however, this is not necessarily the case, as the clinical presentation of this disease is heterogeneous. LABD clinically presenting as Stevens–Johnson syndrome ( SJS ) or toxic epidermal necrolysis ( TEN ) is an infrequent, yet well‐described phenomenon. Most cases of LABD are idiopathic, but some cases are drug‐induced. Multiple drugs have been implicated in the development of LABD . We report a case of piperacillin–tazobactam‐induced LABD presenting clinically as SJS / TEN overlap. This is the first reported case of a strong causal association between piperacillin‐tazobactam and the development of LABD .