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Piperacillin–tazobactam‐induced linear IgA bullous dermatosis presenting clinically as Stevens–Johnson syndrome/toxic epidermal necrolysis overlap
Author(s) -
Adler N. R.,
McLean C. A.,
Aung A. K.,
Goh M. S. Y.
Publication year - 2017
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/ced.13030
Subject(s) - toxic epidermal necrolysis , dermatology , medicine , piperacillin/tazobactam , piperacillin , tazobactam , biology , bacteria , pseudomonas aeruginosa , genetics
Summary Linear IgA bullous dermatosis ( LABD ) is a subepidermal autoimmune bullous disease characterized by linear IgA deposition at the basement membrane zone, which is visualized by direct immunofluorescence. Patients with LABD typically present with widespread vesicles and bullae; however, this is not necessarily the case, as the clinical presentation of this disease is heterogeneous. LABD clinically presenting as Stevens–Johnson syndrome ( SJS ) or toxic epidermal necrolysis ( TEN ) is an infrequent, yet well‐described phenomenon. Most cases of LABD are idiopathic, but some cases are drug‐induced. Multiple drugs have been implicated in the development of LABD . We report a case of piperacillin–tazobactam‐induced LABD presenting clinically as SJS / TEN overlap. This is the first reported case of a strong causal association between piperacillin‐tazobactam and the development of LABD .