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Psoriasis and metabolic syndrome in children: current data
Author(s) -
Pietrzak A.,
Grywalska E.,
Walankiewicz M.,
Lotti T.,
Roliński J.,
Myśliński W.,
Chabros P.,
PiekarskaMyślińska D.,
Reich K.
Publication year - 2017
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/ced.13014
Subject(s) - psoriasis , current (fluid) , medicine , dermatology , pediatrics , intensive care medicine , engineering , electrical engineering
Summary Background The prevalence of cardiovascular and metabolic disorders in paediatric patients with psoriasis is not well established. Aim To conduct a meta‐analysis of previously published studies dealing with the occurrence of metabolic disorders in children with psoriasis. Methods Data from 7 studies with a total of 965 children with psoriasis were analysed using a random effects model. Results Prevalence of metabolic syndrome (MetS) was significantly higher in patients with psoriasis than in healthy controls ( HC s). In most studies, significantly decreased levels of high‐density lipoprotein ( HDL ) cholesterol were found in children with psoriasis. Mean level of HDL cholesterol in patients with psoriasis was 2.05 mg/ dL lower than in HC s. Patients with psoriasis and HC s did not differ significantly in their mean triglyceride levels, although the difference was at a threshold of statistical significance. Mean level of fasting glucose in children with psoriasis was 5.75 mg/ dL higher than in HC s ( P < 0.01). The two groups did not differ significantly in mean waist circumference or in systolic and diastolic arterial pressures. Conclusions Decreased levels of HDL cholesterol and increased concentrations of fasting glucose may represent very early stages of MetS in children with psoriasis. However, a large population‐based study is needed to establish the relationship between psoriasis and MetS in children, including the environmental, genetic and immunological factors leading to their co‐occurrence.