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Presence of the Merkel cell polyomavirus in Merkel cell carcinoma combined with squamous cell carcinoma in a patient with chronic arsenism
Author(s) -
Chou T.C.,
Tsai K.B.,
Wu C.Y.,
Hong C.H.,
Lee C.H.
Publication year - 2016
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/ced.12954
Subject(s) - merkel cell polyomavirus , merkel cell carcinoma , basal cell , merkel cell , medicine , pathology , cancer research , polyomavirus infections , dermatology , cell , carcinoma , oncology , biology , bk virus , kidney transplantation , transplantation , genetics
Summary We present a case of Merkel cell carcinoma ( MCC ) coincident with squamous cell carcinoma ( SCC ) on the breast of a woman with chronic arsenism. This case demonstrates the distinct association of chronic arsenism with two different primary cutaneous carcinomas. Merkel cell polyomavirus ( MCP yV) was identified in the lesional skin of the MCC but not in that of the SCC , suggesting there are different interactions of MCP yV in the pathogenesis of SCC and MCC related to arsenic. Physicians need to be vigilant in the occurrence of both SCC and MCC in patients with chronic arsenism. To our knowledge, this is the first study to show the presence of MCP yV in the MCC but not the SCC portion of an arsenic‐induced tumour.