Decreased peroxisome proliferator‐activated receptor γ level and signalling in sebaceous glands of patients with acne vulgaris | Zendy

Dozsa A. | Zendy; Mihaly J. | Zendy; Dezso B. | Zendy; Csizmadia E. | Zendy; Keresztessy T. | Zendy; Marko L. | Zendy; Rühl R. | Zendy; Remenyik E. | Zendy; Nagy L. | Zendy

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Decreased peroxisome proliferator‐activated receptor γ level and signalling in sebaceous glands of patients with acne vulgaris

Author(s) -

Dozsa A.,

Mihaly J.,

Dezso B.,

Csizmadia E.,

Keresztessy T.,

Marko L.,

Rühl R.,

Remenyik E.,

Nagy L.

Publication year - 2016

Publication title -

clinical and experimental dermatology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.587

H-Index - 78

eISSN - 1365-2230

pISSN - 0307-6938

DOI - 10.1111/ced.12794

Subject(s) - acne , sebaceous gland , peroxisome proliferator activated receptor , lipid metabolism , endocrinology , activator (genetics) , medicine , endogeny , receptor , transcription factor , peroxisome , adipose tissue , biology , arachidonic acid , biochemistry , gene , enzyme , genetics

Summary Little is known about the altered lipid metabolism‐related transcriptional events occuring in sebaceous glands of patients with acne vulgaris. Peroxisome proliferator‐activated receptor ( PPAR )γ, a lipid‐activated transcription factor, is implicated in differentiation and lipid metabolism of sebocytes. We have observed that PPAR γ and its target genes, ADRP (adipose differentiation related protein) and PGAR ( PPAR γ angioprotein related protein) are expressed at lower levels in sebocytes from patients with acne than in those from healthy controls ( HC s) Furthermore, endogenous PPAR γ activator lipids such as arachidonic acid‐derived keto‐metabolites (e.g. 5 KETE , 12 KETE ) are increased in acne‐involved and nonacne‐involved skin of patients with acne, compared with skin from healthy individuals. Our findings highlight the possible anti‐inflammatory role of endogenous ligand‐activated PPAR γ signaling in human sebocyte biology, and suggest that modulating PPAR γ‐ expression and thereby signaling might be a promising strategy for the clinical management of acne vulgaris.

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