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Decreased peroxisome proliferator‐activated receptor γ level and signalling in sebaceous glands of patients with acne vulgaris
Author(s) -
Dozsa A.,
Mihaly J.,
Dezso B.,
Csizmadia E.,
Keresztessy T.,
Marko L.,
Rühl R.,
Remenyik E.,
Nagy L.
Publication year - 2016
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/ced.12794
Subject(s) - acne , sebaceous gland , peroxisome proliferator activated receptor , lipid metabolism , endocrinology , activator (genetics) , medicine , endogeny , receptor , transcription factor , peroxisome , adipose tissue , biology , arachidonic acid , biochemistry , gene , enzyme , genetics
Summary Little is known about the altered lipid metabolism‐related transcriptional events occuring in sebaceous glands of patients with acne vulgaris. Peroxisome proliferator‐activated receptor ( PPAR )γ, a lipid‐activated transcription factor, is implicated in differentiation and lipid metabolism of sebocytes. We have observed that PPAR γ and its target genes, ADRP (adipose differentiation related protein) and PGAR ( PPAR γ angioprotein related protein) are expressed at lower levels in sebocytes from patients with acne than in those from healthy controls ( HC s) Furthermore, endogenous PPAR γ activator lipids such as arachidonic acid‐derived keto‐metabolites (e.g. 5 KETE , 12 KETE ) are increased in acne‐involved and nonacne‐involved skin of patients with acne, compared with skin from healthy individuals. Our findings highlight the possible anti‐inflammatory role of endogenous ligand‐activated PPAR γ signaling in human sebocyte biology, and suggest that modulating PPAR γ‐ expression and thereby signaling might be a promising strategy for the clinical management of acne vulgaris.