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Paradoxical exacerbation of chronic plaque psoriasis by sorafenib
Author(s) -
Yiu Z. Z. N.,
Ali F. R.,
Griffiths C. E. M.
Publication year - 2016
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/ced.12788
Subject(s) - sorafenib , psoriasis , medicine , exacerbation , vegf receptors , vascular endothelial growth factor , dermatology , drug , tyrosine kinase inhibitor , pharmacology , hepatocellular carcinoma , cancer
Summary Vascular endothelial growth factor ( VEGF ) antagonists have been investigated as a potential treatment for psoriasis, but there have been reports of VEGF antagonists triggering and/or exacerbating pre‐existing psoriasis. We present the case of a 61‐year old‐man with exacerbation of pre‐existing psoriasis after treatment with sorafenib, a small molecule inhibitor of the tyrosine kinase domain of the VEGF receptor, and we review the literature for other published cases of sorafenib‐induced or sorafenib‐exacerbated psoriasis. Clinicians, including both dermatologists and oncologists, should be aware of this potential side‐effect of sorafenib in addition to the other cutaneous side effects reported for this drug.