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micro RNA profiling for early detection of nonmelanoma skin cancer
Author(s) -
Balci S.,
Ayaz L.,
Gorur A.,
Yildirim Yaroglu H.,
Akbayir S.,
Dogruer Unal N.,
Bulut B.,
Tursen U.,
Tamer L.
Publication year - 2016
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/ced.12736
Subject(s) - skin cancer , microrna , medicine , profiling (computer programming) , dermatology , cancer , biology , computer science , genetics , gene , operating system
Summary Background micro RNA s (mi RNA s) are single‐stranded, noncoding RNA molecules. Given the vast regulatory potential of mi RNA s and their often tissue‐specific and disease‐specific expression patterns, mi RNA s are being assessed as possible biomarkers to aid diagnosis and prediction of different types and stages of cancers, including skin cancer. Basal cell carcinoma ( BCC ) and squamous cell carcinoma ( SCC ) are the most common forms of nonmelanoma skin cancer ( NMSC ). BCC originates from the basal layer of the epidermis, while SCC arises from epidermal keratinocytes or from the dermal appendages. Although NMSC s are currently the most common types of malignancies, both BCC and SCC have a better than 95% cure rate if detected early. Aim To identify plasma mi RNA s suitable for early detection of NMSC . Methods Expression profiles of 741 mi RNA s were evaluated using high‐throughput real‐time quantitative PCR from plasma samples in 42 patients with NMSC and 282 healthy controls ( HC s). Results Our results demonstrated that in patients with NMSC , compared with HC s, expression levels of miR‐30e‐3p, miR‐145‐5p, miR‐186‐5p and miR‐875‐5p were significantly ( P < 0.05) upregulated, while those of miR‐19a‐3p, miR‐25‐3p, miR‐30a‐5p, miR‐451 and miR‐576‐3p were significantly downregulated. Conclusion Our study suggests that the mi RNA s with significant changes in expression (miR‐19a‐3p, miR‐25‐3p, miR‐30a‐5p, miR‐145‐5p and miR‐186‐5p) could serve as novel noninvasive biomarkers for detection of NMSC .