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Hypereosinophilic syndrome: an indolent rash with a serious cardiac complication
Author(s) -
Merika E. E.,
Lefroy D.,
Milojkovic D.,
Wakelin S. H.
Publication year - 2016
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/ced.12709
Subject(s) - medicine , rash , complication , hypereosinophilic syndrome , dermatology , cardiology , eosinophilia
Summary Idiopathic hypereosinophilic syndrome ( HES ) is a rare disorder, characterized by prominent blood or tissue eosinophilia with ensuing tissue damage, which is diagnosed after exclusion of underlying diseases known to cause HES . Sustained eosinophilia is associated with cardiac disease, including endomyocardial thrombosis and fibrosis, leading to restrictive cardiomyopathy, valvular dysfunction and increased thrombotic tendency. Aneurysmal coronary artery disease ( CAD ) occurring in the absence of stenotic atherosclerotic plaques is extremely rare. We present a case of idiopathic HES in a 30‐year‐old woman with asymptomatic multianeurysmal CAD and a sinus of Valsalva aneurysm, and discuss a brief review of the literature and management strategies.