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Evaluation of Lewis blood group antigens and secretor status in pemphigus vulgaris
Author(s) -
ShahidiDadras M.,
Golfeshan A.
Publication year - 2016
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/ced.12707
Subject(s) - pemphigus vulgaris , saliva , phenotype , immunology , medicine , antigen , population , biology , genetics , gene , environmental health
Summary Background There has not been publication of any previous study about the role of secretory status or Lewis phenotypes in the mechanisms of pemphigus vulgaris ( PV ). Aim To evaluate the frequencies of secretory status and Lewis phenotypes in patients with PV compared with healthy controls ( HC s) in order determine their roles in this autoimmune disease. Methods In total, 50 patients and 100 age‐ and sex‐matched HC s were selected to form the study population, and 2 mL blood were collected from each subject to identify their Lewis phenotype. In subjects with the Le(a−b−) phenotype, saliva was also collected to determine secretor status. Results The frequency of the nonsecretor ( NS ) phenotypes Le(a+b−) and Le(a−b−) together was significantly higher in patients than in HC s: 34/50 (68%)vs. 26/100 (26%), respectively ( P < 0.001). All the patients and HC subjects with the Le (a−b−) phenotype were found to be NS by haemagglutination inhibition assay of saliva samples. Conclusion Based on our results, it seems that Le/b‐negative NS individuals are more susceptible to PV .