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Serum IL ‐33 levels are increased in patients with psoriasis
Author(s) -
Mitsui A.,
Tada Y.,
Takahashi T.,
Shibata S.,
Kamata M.,
Miyagaki T.,
Fujita H.,
Sugaya M.,
Kadono T.,
Sato S.,
Asano Y.
Publication year - 2016
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/ced.12670
Subject(s) - psoriasis , medicine , rheumatoid arthritis , tumor necrosis factor alpha , psoriatic arthritis , cytokine , immunology , inflammation , interleukin , arthritis , endocrinology
Summary Background Interleukin ( IL )‐33 is a recently identified cytokine, which is a member of the IL ‐1 family and binds to a heterodimeric receptor comprising ST 2 (suppression of tumorigenicity 2) and IL ‐1 receptor accessory protein. Serum levels of IL ‐33 have been reported to be upregulated in various T helper ( T h)1/ T h17‐mediated diseases, such as rheumatoid arthritis and inflammatory bowel disease. IL ‐33 expression is increased in lesional skin in patients with psoriasis, but serum levels in patients with psoriasis have not yet been studied. Aim To study serum IL ‐33 levels in patients with psoriasis, a T h1/ T h17‐mediated skin disease, before and after anti‐tumour necrosis factor ( TNF )‐α therapy. Methods Serum IL ‐33 levels were measured in patients with psoriasis vulgaris ( PV ), psoriatic arthritis ( P s A ) or pustular psoriasis ( PP ), and compared with those of healthy controls. Associations between serum IL ‐33 levels and serum TNF ‐α, IL ‐6, vascular endothelial growth factor and C ‐reactive protein levels were also studied. In addition, the effect of IL ‐33 stimulation on IL ‐6, IL ‐8, TNF ‐α and VEGF secretion by human keratinocyte was analysed. Results Serum IL ‐33 levels in patients with PV , P s A and PP were significantly higher than those in healthy controls. Serum IL ‐33 levels correlated with serum TNF ‐α levels in patients with psoriasis, and decreased after anti‐ TNF ‐α therapy. IL ‐33 stimulated IL ‐6 and IL ‐8 secretion by human keratinocytes. Conclusions These results suggest that serum IL ‐33 levels generally reflect increased inflammation in patients with psoriasis.