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Association of ApaI and BsmI polymorphisms with vitiligo risk: a meta‐analysis
Author(s) -
Li L.,
Wu Y.,
Li L.,
Cai Y.F.,
Geng L.,
Gao X.H.,
Chen H.D.
Publication year - 2015
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/ced.12633
Subject(s) - china , medicine , vitiligo , family medicine , dermatology , library science , history , archaeology , computer science
Summary Background It has been reported that polymorphisms of the vitamin D receptor gene ( VDR ) such as ApaI or BsmI may affect the risk of vitiligo. However, the results have been inconsistent. Aim To evaluate the association between two common polymorphisms ( ApaI and BsmI ) in the VDR gene and the susceptibility to vitiligo. Methods The PubMed, Cochrane Library and China National Knowledge Infrastructure ( CNKI ) databases were searched, and OR with 95% CI was calculated. The strength of association and vitiligo risk was assessed under five genetic models: allele, dominant, recessive, homozygous and heterozygous. Results Six relevant studies were identified, including five studies that assessed the ApaI polymorphism and four the BsmI polymorphism (some overlapped). The meta‐analysis results indicated that either the ApaI or the BsmI gene polymorphism may increase the risk of vitiligo in East Asian populations (aa + Aa vs. AA : OR = 1.40, 95% CI 1.01–1.96, P < 0.05; bb vs. Bb + BB : OR = 1.32, 95% CI 1.09–1.59, P < 0.01). No publication bias was detected in this meta‐analysis. Conclusion The current meta‐analysis suggests that the ApaI a allele or BsmI bb genotype are associated with the risk of vitiligo in East Asian populations. Thus, these polymorphisms could be potential biomarkers for early detection of vitiligo.