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Chronic urticaria due to autoreactivity to progesterone
Author(s) -
WingateSaul L.,
Rymer J.,
Greaves M. W.
Publication year - 2015
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/ced.12632
Subject(s) - medicine , goserelin , menopause , menstrual cycle , gynecology , dermatology , hormone , cancer , breast cancer
Summary A 23‐year‐old, regularly menstruating woman presented with recurrent urticarial eruptions, which occurred premenstrually. A skin prick test was positive for progesterone, but the urticaria was unresponsive to standard treatments. The patient was treated with goserelin (Zoladex), which suppressed her menstrual cycle, leading to the resolution of her symptoms. Subsequent flares were controlled by further goserelin injections, and the urticaria is currently in remission. However, the risks of inducing menopause artificially are significant, and alternative long‐term solutions may need to be considered in the event of a relapse.