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Diffuse dermal angiomatosis associated with severe atherosclerosis: two cases and review of the literature
Author(s) -
Crickx E.,
Saussine A.,
VigPennamen M. D.,
Cordoliani F.,
Mouly F.,
Bagot M.,
Rybojad M.
Publication year - 2015
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/ced.12565
Subject(s) - saint , library science , medicine , classics , art , art history , computer science
Summary Diffuse dermal angiomatosis ( DDA ) is a rare condition characterized by endothelial proliferation in the reticular dermis. Several diseases have been associated with DDA , including peripheral arterial disease ( PAD ). We report two cases of DDA associated with PAD . Patient 1 was a 71‐year‐old woman, who presented with painful necrotic ulcerations on her trunk and a medical history of PAD . Skin biopsy revealed a dermal proliferation of endothelial cells, and despite medical treatment, she died 1 month later. Patient 2 was an 81‐year‐old man, who presented with an erythematous, bluish plaque of the shoulder. He was a heavy smoker, with severe PAD . Biopsy showed dermal capillary hyperplasia, with a few fibrin thrombi, and follow‐up only was recommended. In both cases, laboratory tests and Doppler ultrasonography ruled out other thrombotic conditions and vascularitis. DDA is a rare complication of PAD , and the optimum medical treatment remains to be clarified, especially when revascularization has failed or is not possible, as in our cases.