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A 14‐year paraneoplastic rash: urticarial vasculitis and dermal binding bullous pemphigoid secondary to chronic lymphocytic leukaemia
Author(s) -
Kassim J. M.,
Igali L.,
Levell N. J.
Publication year - 2015
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/ced.12553
Subject(s) - medicine , bullous pemphigoid , rash , dermatology , chronic lymphocytic leukemia , chemotherapy , vasculitis , pathology , immunology , leukemia , antibody , disease
Summary A 72‐year‐old woman with a 14‐year history of urticarial vasculitis ( UV ) and a 13‐year history of bullous pemphigoid ( BP ) presented with associated progressive chronic lymphocytic leukaemia ( CLL ). Both skin conditions responded poorly to treatment, until chemotherapy for CLL was commenced. The skin features showed a clear paraneoplastic course, resolving with chemotherapy and recurring when the CLL relapsed and the lymphocyte count rose above 5 × 10 9 /L. No case of UV secondary to CLL , and very few cases of BP related to CLL have been reported, and no paraneoplastic rash of any type lasting 14 years has been reported previously.