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Prophylactic and therapeutic efficacy of pyridoxine supplements in the management of hand–foot syndrome during chemotherapy: a meta‐analysis
Author(s) -
Jo S. J.,
Shin H.,
Jo S.,
Kwon O.,
Myung S.K.
Publication year - 2015
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/ced.12538
Subject(s) - medicine , family medicine , library science , dermatology , computer science
Summary Background Hand–foot syndrome ( HFS ) is a common cutaneous side effect of certain systemic chemotherapeutic agents. Aim To assess the efficacy of pyridoxine supplements in the management of HFS . Methods We searched PubMed, EMBASE and the Cochrane Central Register of Controlled Trials for studies reporting the efficacy of pyridoxine supplements to manage HFS . We performed a meta‐analysis using HFS incidence and improvement rates to measure the preventive and treatment efficacy of pyridoxine supplementation. Results We assessed eight studies [two retrospective studies, two prospective comparative trials and four randomized controlled trials ( RCT s)] for preventive efficacy and three studies (one RCT and two non‐ RCT s) for treatment efficacy. A random‐effects meta‐analysis did not find any significant association between prophylactic pyridoxine supplementation and HFS development [relative risk ( RR ) = 0.95; 95% CI 0.87–1.05) or any significant preventive efficacy against HFS in subgroup meta‐analyses of study design, chemotherapeutic agents, pyridoxine dose, HFS severity, publication year or observation period. However, pyridoxine did show significant efficacy in treating HFS ( RR = 1.75; 95% CI 1.09–2.80), but did not show efficacy in the only RCT ( RR = 1.12; 95% CI 0.58–2.14). Conclusions We found no clinical evidence to support the use of pyridoxine supplements to prevent HFS during chemotherapy.