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Generalized pustular psoriasis following allogeneic stem cell transplantation
Author(s) -
George L.,
Mathews V.,
George B.,
Thomas M.,
Pulimood S. A.
Publication year - 2015
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/ced.12508
Subject(s) - generalized pustular psoriasis , medicine , transplantation , psoriasis , stem cell , dermatology , pustular psoriasis , immunology , biology , genetics
Summary Development of psoriasis following allogeneic stem cell transplantation ( SCT ) is rare, and has been described once previously, following SCT from a sibling donor with psoriasis. This condition should be differentiated from psoriasiform graft‐versus‐host disease (Gv HD ) by histopathology. We describe a 9‐year‐old boy who developed generalized pustular psoriasis 2 months after allogeneic SCT from an HLA ‐identical sibling donor with no history of psoriasis. Diagnosis was confirmed by clinical features and multiple skin biopsies, which helped to exclude Gv HD . The skin lesions responded well to treatment with acitretin. Psoriasis should be considered in the differential diagnosis of skin rash following SCT .