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Familial aggregation of moderate to severe plaque psoriasis
Author(s) -
Di Lernia V.,
Ficarelli E.,
Lallas A.,
Ricci C.
Publication year - 2014
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/ced.12401
Subject(s) - psoriasis , medicine , family aggregation , proband , dermatology , disease , family history , population , first degree relatives , genetics , biology , environmental health , mutation , gene
Summary Background Psoriasis is a highly heritable disease. It has been suggested that psoriasis is preferentially transmitted from fathers. Aim To evaluate the degree of familial aggregation of psoriasis; to determine the recurrence risk ratio (λ R ) of psoriasis in first, second and third degree relatives of patients with psoriasis; and to investigate the transmission patterns of the disease and their relationships with the clinical profiles of patients. Methods A cross‐sectional study on 640 consecutive, unrelated adult patients with chronic plaque psoriasis was performed. The prevalence of psoriasis in first, second and third degree relatives of the patients was determined, and the λ R was calculated under the assumption of a population prevalence of 2%. Age of onset and presence of facial, hand and foot psoriasis were evaluated in probands with paternal vs. maternal transmission. Results A positive familial history of psoriasis was found in 380 patients (59.37%). Of these, 174 (27.18%) had at least one parent with psoriasis, with a λ R of 13.59, while 106 patients (16.56%) had at least one second degree relative with psoriasis, and 34 patients (5.31%) had one third degree relative with psoriasis. No parent‐of‐origin effect in transmission of psoriasis from affected parent to offspring was observed, and there were no significant differences in the clinical profiles of the disease between patients grouped by transmission pattern of psoriasis. Conclusions These results show a high familial recurrence risk of psoriasis, and suggest a balanced parental t ransmission of the disease.