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Effect of psoriasis activity on epidermal growth factor ( EGF ) and the concentration of soluble EGF receptor in serum and plaque scales
Author(s) -
Flisiak I.,
SzterlingJaworowska M.,
Baran A.,
RogalskaTaranta M.
Publication year - 2014
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/ced.12356
Subject(s) - epidermal growth factor , psoriasis , endocrinology , medicine , receptor , pathogenesis , psoriasis area and severity index , positive correlation , immunology
Summary Background Epidermal growth factor receptors ( EGFR s) are overexpressed in psoriatic keratinocytes, and regulate cell growth, proliferation and differentiation through binding to epidermal growth factor ( EGF ). The role of EGF and EGFR s in the pathogenesis of psoriasis and the contribution of their measurement to psoriasis management are still unknown. Aim To evaluate serum concentrations of EGF , soluble (s) EGFR s and EGF content in psoriatic scales of patients with severe psoriasis, and to analyse their association with the clinical activity of the disease. Methods Serum samples and plaque scales were collected from 51 patients with plaque‐type psoriasis. Concentrations of EGF and s EGFR in serum and of EGF in scales were measured using enzyme immunoassay. Data were analysed with respect to baseline P soriasis A rea and S everity I ndex ( PASI ). Results Mean serum EGF concentration in patients was higher than in controls (701 ± 72 vs. 586 ± 63 pg/mL), but the difference was not significant. Mean serum concentration of s EGFR was significantly lower than controls (40.8 ± 1.4 vs. 86.4 ± 11.3 ng/mL, P < 0.001). Serum levels of EGF showed a significant positive correlation and EGFR showed a significant negative correlation with PASI ( P < 0.05). No correlation was seen between PASI and EGF content in scales or between EGF and s EGFR levels. Serum EGF concentrations reached the highest mean level (914 ± 138 pg/mL) in patients with PASI > 20, and this was significantly higher than the mean of 414 ± 82 pg/mL in the group with PASI < 10. Mean s EGFR serum concentrations remained significantly lower than those of controls, irrespective of disease severity. Conclusions Compared with controls, patients with psoriasis had increased EGF and decreased s EGFR levels in serum. EGF and s EGFR levels correlated with disease severity.