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IgG4‐related skin lesions: case report and review of the literature
Author(s) -
Kempeneers D.,
Hauben E.,
De Haes P.
Publication year - 2014
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/ced.12325
Subject(s) - medicine , dermatology , library science , computer science
Summary IgG4‐related disease (IgG4‐ RD ) is a systemic disease, mostly affecting the pancreas. It presents as accumulation of IgG4‐producing plasma cells in various tissues. Other possible affected organs include the lacrimal glands, salivary glands, lungs, kidneys, liver, bile duct, retroperitoneum, breast, aorta, pituitary gland and prostate. A cutaneous presentation has also been described in the literature, and might be the initial presenting feature of IgG4‐ RD . We describe a 73‐year‐old white man who presented with two infiltrated, erythematous nodules on his abdomen. The histopathological characteristics were highly suggestive of IgG4‐related cutaneous disease. Immunohistochemical stains were positive for IgG4. In the past, the patient's other organs had also been affected by IgG4‐ RD . Cutaneous presentation of IgG4‐ RD has been described previously in the literature but only in Asian patients (both East and South Asian). We also provide an overview of previously reported cutaneous manifestations of IgG4‐ RD .