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Eosinophilic fasciitis associated with hypereosinophilia, abnormal bone‐marrow karyotype and inversion of chromosome 5
Author(s) -
Ferguson J. S.,
Bosworth J.,
Min T.,
Mercieca J.,
Holden C. A.
Publication year - 2014
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/ced.12228
Subject(s) - medicine , hypereosinophilia , dermatology , family medicine , general surgery , pathology , eosinophilia
Summary We report the case of a male patient presenting with eosinophilia, pulmonary oedema and eosinophilic fasciitis ( EF ). He had the classic clinical appearance and magnetic resonance imaging of EF . Cytogenetic analysis of the bone marrow revealed a previously undescribed pericentric inversion of chromosome 5. Overall, the presentation was consistent with a diagnosis of chronic eosinophilic leukaemia, not otherwise specified ( CEL ‐ NOS ). Dermatologists should consult a haematologist in cases of EF , in order to rule out possible haematological malignancies.