Eosinophilic fasciitis associated with hypereosinophilia, abnormal bone‐marrow karyotype and inversion of chromosome 5 | Zendy

Ferguson J. S. | Zendy; Bosworth J. | Zendy; Min T. | Zendy; Mercieca J. | Zendy; Holden C. A. | Zendy

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Eosinophilic fasciitis associated with hypereosinophilia, abnormal bone‐marrow karyotype and inversion of chromosome 5

Author(s) -

Ferguson J. S.,

Bosworth J.,

Min T.,

Mercieca J.,

Holden C. A.

Publication year - 2014

Publication title -

clinical and experimental dermatology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.587

H-Index - 78

eISSN - 1365-2230

pISSN - 0307-6938

DOI - 10.1111/ced.12228

Subject(s) - medicine , hypereosinophilia , dermatology , family medicine , general surgery , pathology , eosinophilia

Summary We report the case of a male patient presenting with eosinophilia, pulmonary oedema and eosinophilic fasciitis ( EF ). He had the classic clinical appearance and magnetic resonance imaging of EF . Cytogenetic analysis of the bone marrow revealed a previously undescribed pericentric inversion of chromosome 5. Overall, the presentation was consistent with a diagnosis of chronic eosinophilic leukaemia, not otherwise specified ( CEL ‐ NOS ). Dermatologists should consult a haematologist in cases of EF , in order to rule out possible haematological malignancies.

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