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Leptin levels in patients with psoriasis: a meta‐analysis
Author(s) -
Zhu K.J.,
Zhang C.,
Li M.,
Zhu C.Y.,
Shi G.,
Fan Y.M.
Publication year - 2013
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/ced.12171
Subject(s) - leptin , psoriasis , medicine , meta analysis , cochrane library , subgroup analysis , gastroenterology , psoriasis area and severity index , endocrinology , obesity , dermatology
Summary Background There have been inconsistent results reported for leptin levels in patients with psoriasis. Aim To evaluate leptin levels in patients with psoriasis using a meta‐analysis of studies comparing leptin levels in controls and in patients with psoriasis. Methods PubMed ( MEDLINE ), EMBASE and the C ochrane L ibrary were searched for relevant papers published in E nglish. Pooled weighted mean differences ( WMD s) and 95% CI s were calculated using random‐effects and fixed‐effects models. Heterogeneity between studies was assessed using the C ochran Q and I 2 statistics. Results In total, 11 studies, comprising 773 patients with psoriasis and 570 healthy controls, were identified. Leptin levels were significantly higher in patients with psoriasis compared with controls ( WMD = 7.24, 95% CI 4.55–9.93; P < 0.001). On stratified analysis, significant differences in leptin levels between patients with psoriasis and controls were reported only in serum samples ( P < 0.001), and not in plasma samples ( P = 0.025). Sensitivity analysis showed that there were no changes in the direction of effect when any one study was excluded. No publication bias was detected. Conclusions Leptin levels are higher in patients with psoriasis compared with those in controls. Future studies are warranted to clarify the association between leptin levels and the pathomechanism of psoriasis.