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Nuclear and cytoplasmic localization of β‐catenin in the nail‐matrix cells and in an onychomatricoma
Author(s) -
Kim C.R.,
Shin H.T.,
Park J.H.,
Lee D.Y.,
Yang J.M.,
Kwon G. Y.,
Jang K.T.,
Lee K.H.,
Shim J. S.
Publication year - 2013
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/ced.12139
Subject(s) - cytoplasm , catenin , nail (fastener) , nail matrix , matrix (chemical analysis) , nuclear matrix , cell nucleus , microbiology and biotechnology , pathology , medicine , biology , chemistry , dermatology , nail plate , materials science , genetics , dna , wnt signaling pathway , signal transduction , chromatography , metallurgy , chromatin , psoriasis
Summary β‐catenin plays an important role in hair morphogenesis. Previously, the nuclear and cytoplasmic localizations of β‐catenin were identified in hair‐matrix cells. To evaluate β‐catenin expression in the nail matrix, we obtained human nail units. Immunohistochemistry for β ‐ catenin was used to evaluate sections of normal nail units and of sections from a single case of onychomatricoma. In the nail unit, β‐catenin was expressed in the nucleus and cytoplasm of the suprabasal nail‐matrix cells. Of the other epithelial‐cell types, only the cell membrane was β‐catenin‐positive. In the nail tissue from the onychomatricoma case, β‐catenin was expressed in the nucleus and cytoplasm of the upper epithelial layers. Our result suggests that β‐catenin plays an important role in nail formation. In addition, β‐catenin expression in onychomatricoma supports the presence of nail‐matrix cells in this condition. To our knowledge, this is the first report of β‐catenin expression in the nucleus and cytoplasm of the nail matrix.