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Long‐term successful healing of ulcerated necrobiosis lipoidica after topical therapy with becaplermin
Author(s) -
Tauveron V.,
Rosen A.,
Khashoggi M.,
AbdallahLotf M.,
Machet L.
Publication year - 2013
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/ced.12123
Subject(s) - necrobiosis lipoidica , medicine , dermatology , diabetes mellitus , endocrinology
Summary We report a case of chronic leg ulceration occurring in a patient with necrobiosis lipoidica ( NL ). After many topical treatments had failed to achieve healing, treatment with topical becaplermin was started, which resulted in rapid improvement and ultimately complete healing of the ulceration. Treatment of ulcerated NL is often disappointing. Many topical and systemic drugs have been tried. Becaplermin is a platelet‐derived growth factor indicated for the treatment of neuropathic diabetic ulcers measuring < 50 mm in size. To our knowledge, this is only the second case reported in the literature of ulcerated NL successfully treated with becaplermin.