Premium
Relapsing lymphomatoid papulosis after allogenic bone‐marrow transplant
Author(s) -
Miquel J.,
Vourc'hJourdain M.,
Thomas C.,
Cassagnau E.,
Stalder JF.,
Barbarot S.
Publication year - 2013
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/ced.12101
Subject(s) - lymphomatoid papulosis , medicine , dermatology , humanities , art , pathology , mycosis fungoides , lymphoma
Summary Lymphomatoid papulosis (LyP) is a rare cutaneous lymphoproliferative disorder in children, which can rarely be associated with a cutaneous or systemic lymphoma. We report a 13‐year‐old girl who presented with typical LyP and pathological features of subtype A. Six months later, the patient presented with rapidly progressive peripheral and systemic lymphadenopathy. On examination of a lymph‐node biopsy, a lymphoid infiltrate negative for anaplastic lymphoma kinase ( ALK ) and positive for CD 30 was found, suggestive of systemic anaplastic large T‐cell lymphoma (S‐ ALCL ). The patient was treated with chemotherapy, followed by allogeneic bone‐marrow transplant ( BMT ). Over the following 6 years, she presented with biopsy‐confirmed LyP relapses with complete cutaneous, peripheral‐blood and bone‐marrow chimerism. This is only the third reported paediatric association of S‐ ALCL with LyP to our knowledge, and seems to be the first paediatric case of recurrent relapses of LyP after bone‐marrow allograft for S‐ ALCL with total (100%) cutaneous and bone‐marrow chimerism. LyP occurring after allogenic BMT does not appear to be donor‐derived.