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Expression of CD 39/Entpd1 on granuloma‐composing cells and induction of Foxp3‐positive regulatory T cells in sarcoidosis
Author(s) -
Fujimura T.,
Kambayashi Y.,
Aiba S.
Publication year - 2013
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/ced.12094
Subject(s) - sarcoidosis , foxp3 , granuloma , il 2 receptor , granuloma annulare , medicine , pathology , immunology , regulatory t cell , t cell , immune system
Summary Background Regulatory T cells (Tregs), together with tolerogenic dendritic cells ( tDC s) are involved in maintaining peripheral tolerance. A recent report suggested both Tregs and tDC s may be pathogenic in granulomatous skin disorders. Aim To examined the expression of CD 39 on granuloma‐composing cells and Foxp3‐positive Tregs in the skin in two representative granulomatous diseases, sarcoidosis and granuloma annulare ( GA ). Methods We immunohistologically examined expression of CD 39 on granuloma‐composing cells and expression of Foxp3 on CD 4+ or CD 25+ cells in fixed sections of lesional skin from 16 patients with sarcoidosis and five patients with GA . Results The granuloma‐composing cells expressed CD 39 in both sarcoidosis and GA . Significant numbers of CD 4+ Foxp3+ Tregs were present diffusely throughout the granulomatous tissues in sarcoidosis, whereas Tregs in GA existed only at the peripheral lesion of palisading granulomatous tissue. Conclusions There was infiltration of increased numbers of Foxp3+ Tregs around the CD 39+ granuloma‐composing cells in both GA and sarcoidosis.