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Genetic variants of the genes encoding zinc finger protein 313 and interleukin‐13 confer a risk for psoriasis in a C hinese U ygur population
Author(s) -
Feng Y.Y.,
Sun L.D.,
Zhang C.,
Zuo X.B.,
Kang X.J.,
Wu W.D.,
Zhang D.Z.,
Wu X.J.,
Zhang X.J.,
m Pu X.
Publication year - 2013
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/ced.12049
Subject(s) - psoriasis , single nucleotide polymorphism , genome wide association study , genetics , population , genotyping , snp , medicine , multifactor dimensionality reduction , locus (genetics) , genetic association , genotype , gene , biology , immunology , environmental health
Summary Background Recent work using genome–wide association studies ( GWAS ) in Chinese Han and white populations have discovered several novel psoriasis susceptibility genes. Aim To examine whether the risk loci for psoriasis identified in previous GWAS in a white population are also associated with psoriasis in a C hinese U ygur population in X injiang. Methods Genotyping analysis of eight single‐nucleotide polymorphisms ( SNP s) associated with psoriasis was performed for 539 patients with psoriasis and 749 controls, all of C hinese U ygur descent, using a commercial assay. Results Two SNP s had an association with psoriasis in this C hinese U ygur population: SNP rs495337 in the gene encoding for zinc finger protein 313 ( P < 0.001; OR = 0.80) and SNP rs20541 of the gene encoding for interleukin‐13 ( P < 0.001; OR = 0.82). In subgroup analyses, the two SNP s were significantly associated ( P < 0.05) with type I psoriasis, Rs495337 showed statistically difference between positive family history of psoriasis patients and controls whereas rs20541 might preferentially associated with negative family history psoriasis patients. Interestingly, using multifactor dimensionality reduction, a significant two‐locus interaction was seen between rs495337 and rs20541, with a crossvalidation consistency of 4/5 and average balanced prediction (accuracy 55.5%, P < 0.001). Conclusions ZNF 313 and IL ‐13 are associated with risk for psoriasis in a C hinese U ygur population, and there is an effect of interaction between the two genes on this risk.