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Age‐associated changes in chronic rhinosinusitis endotypes
Author(s) -
Ryu Gwanghui,
Dhong HunJong,
Park Minsu,
Hwang Na Young,
Kim DongKyu,
Kim Hyo Yeol,
Chung SeungKyu,
Rhee ChaeSeo,
Cho SeongHo,
Hong Sang Duk,
Kim Dae Woo
Publication year - 2020
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/cea.13586
Subject(s) - medicine , nasal polyps , proinflammatory cytokine , immunology , atopy , cytokine , eosinophilia , inflammation , sinusitis , eosinophilic , disease , allergy , pathology
Background Immunologic function in innate and adaptive immunity changes with the ageing process. Thus, age‐related cytokine profiles in chronic rhinosinusitis (CRS) need to be investigated for precision medicine. Objective The objective of this study was to characterize age‐related changes in immunologic profiles according to CRS subtypes. Methods Subjects in control (n = 29), CRS without nasal polyps (CRSsNP, n = 86), and CRS with nasal polyps (eosinophilic NP: ENP, n = 81; non‐eosinophilic NP: NENP, n = 113) were enrolled in this study. Twenty markers for type 1/2/3 inflammation and other inflammatory processes were measured in homogenates of sinonasal tissues and statistically analysed. Results In control tissues, type 2/3 and proinflammatory mediators showed an inverse correlation with age. CRSsNP and NENP showed an age‐related increase in type 2 cytokines and a decline in type 3 cytokines. Interestingly, the age‐related decrease in type 3 mediators was associated with those of CT scores in NENP. ENP showed an age‐related increase in type 3 cytokines with type 2 mediators sustained at high levels. Smokers with ENP demonstrated age‐associated increases in type 1/2/3 mediators as well as CT scores. These age‐related patterns in each CRS were confirmed by statistically adjusting atopy status, smoking history, and disease duration. Conclusion Age‐associated cytokine changes differed among CRS subtypes and control tissues. CRSsNP and NENP demonstrated a decline in type 3 mediators and increase in type 2 mediators, whereas type 3 mediators increased with age in ENP.