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The role of innate immunity in asthma development and protection: Lessons from the environment
Author(s) -
Pivniouk Vadim,
Gimenes Junior Joao Antonio,
Honeker Linnea K.,
Vercelli Donata
Publication year - 2020
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/cea.13508
Subject(s) - innate immune system , immunology , asthma , immunity , inflammation , disease , medicine , immune system , pathogenesis , pathology
Asthma, a complex, chronic disease characterized by airway inflammation, hyperresponsiveness and remodelling, affects over 300 million people worldwide. While the disease is typically associated with exaggerated allergen‐induced type 2 immune responses, these responses are strongly influenced by environmental exposures that stimulate innate immune pathways capable of promoting or protecting from asthma. The dual role played by innate immunity in asthma pathogenesis offers multiple opportunities for both research and clinical interventions and is the subject of this review.