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Should testing be initiated prior to amoxicillin challenge in children?
Author(s) -
Abrams Elissa M.,
BenShoshan Moshe
Publication year - 2019
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/cea.13443
Subject(s) - amoxicillin , provocation test , medicine , allergy , drug allergy , antibiotics , intensive care medicine , drug , narrative review , adverse drug reaction , pediatrics , dermatology , immunology , pharmacology , alternative medicine , pathology , microbiology and biotechnology , biology
Amoxicillin is the most common antibiotic prescribed in children with increasing use over time. While up to 10% of children are labelled as amoxicillin allergic, most children can tolerate amoxicillin after allergy evaluation. It is well documented that the label of amoxicillin allergy in children is associated with adverse health outcomes such as antibiotic‐resistant infections. However, it remains controversial how best to assess children for amoxicillin allergy. While in general it is recommended that skin testing be done prior to drug provocation test in the evaluation of amoxicillin allergy, there is increasing evidence that drug provocation testing could be done in lower risk children without skin testing prior. The goal of this article as a narrative review is to review the strengths and limitations of skin testing prior to drug provocation test in children who have a history of either immediate or non‐immediate, reactions to amoxicillin.