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Chlorhexidine skin symptoms and allergy in dialysis patients and nurses
Author(s) -
Chan Felix L.,
Merchant Asad A.,
Breede Nikki,
Lipszyc Joshua C.,
House Ronald,
Tarlo Susan M.
Publication year - 2019
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/cea.13440
Subject(s) - chlorhexidine , dialysis , allergy , medicine , intensive care medicine , dermatology , immunology , surgery , dentistry
Chlorhexidine is a synthetic biguanide used as an antiseptic in hospital and household products. Chlorhexidine exposure has been implicated in various hypersensitivity reactions, including allergic contact dermatitis, fixed drug eruptions, occupational asthma, generalized urticaria, and anaphylaxis. Perioperative anaphylactic reactions to chlorhexidine have been reported since the 1990s and are typically caused by chlorhexidine-containing lubricants for in-dwelling urinary catheters, chlorhexidine-coated central venous catheters (CVCs), and topical chlorhexidine application. Up to 9% of cases of IgE-mediated perioperative anaphylaxis in the U.K. have been attributable to chlorhexidine; a similar figure has been reported in by a Danish study. This article is protected by copyright. All rights reserved.