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Pru p 7 sensitization is a predominant cause of severe, cypress pollen‐associated peach allergy
Author(s) -
Klingebiel Caroline,
Chantran Yannick,
ArifLusson Rihane,
Ehrenberg Angelica E.,
Östling Jonas,
Poisson Alain,
Liabeuf Valérie,
Agabriel Chantal,
Birnbaum Joëlle,
Porri Françoise,
Sarrat Anne,
Apoil PolAndré,
Vivinus Mylène,
Garnier Lorna,
Chiriac Anca Mirela,
Caimmi DavidePaolo,
Bourrain JeanLuc,
Demoly Pascal,
Guez Stéphane,
Boralevi Franck,
Lovato Bertrand,
Palussière Céline,
Leroy Sylvie,
Bourrier Thierry,
GiovanniniChami Lisa,
Gouitaa Marion,
AferiatDerome Agnès,
Charpin Denis,
Sofalvi Tünde,
CabonBoudard Isabelle,
MassabieBouchat YannPatrick,
Hofmann Bernard,
Bonardel Nathalie,
DronGonzalvez Mireille,
Sterling Benoît,
Carsin Ania,
Vivinus Serge,
Poitevin Bernard,
Nicolau Laureline,
Liautard Geneviève,
Soler Christophe,
Mezouar Soraya,
AnnesiMaesano Isabella,
Mège JeanLouis,
Lidholm Jonas,
Vitte Joana
Publication year - 2019
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/cea.13345
Subject(s) - cypress , sensitization , allergy , cupressaceae , pollen , allergen , immunoglobulin e , immunology , basophil activation , food allergy , medicine , oral allergy syndrome , basophil , biology , botany , antibody
Background Peach is a common elicitor of food allergic reactions. Peach‐induced immediate reactions may occur as benign pollen‐food syndromes, usually due to birch pollen‐related PR‐10 cross‐reactivity in temperate climates, and as potentially severe primary food allergies, predominantly related to nsLTP Pru p 3 in Mediterranean regions. The newly described peach allergen Pru p 7 has gained recent attention as a potential peach allergy severity marker. Sensitization to Pru p 7 and its allergenic homologues of the gibberellin‐regulated protein family occurs in areas with high Cupressaceae tree pollen exposure. Objective We sought to investigate the distribution, clinical characteristics and molecular associations of Pru p 7 sensitization among subjects with suspected peach allergy in different regions of France. Methods Subjects with suspected peach allergy (n = 316) were included. Diagnostic work‐up was performed according to current guidelines, including open food challenge when required. IgE antibody measurements and competition experiments were performed using the ImmunoCAP assay platform. Results Sensitization to Pru p 7 was present in 171 (54%) of all subjects in the study and in 123 of 198 (62%) diagnosed as peach allergic, more than half of whom were sensitized to no other peach allergen. Frequency and magnitude of Pru p 7 sensitization were associated with the presence of peach allergy, the clinical severity of peach‐induced allergic reactions and the level of cypress pollen exposure. Cypress pollen extract completely outcompeted IgE binding to Pru p 7. Pru p 7 was extremely potent in basophil activation tests. Conclusion and Clinical Relevance A subtype of Cupressaceae pollinosis, characterized by Pru p 7 sensitization, can be an underlying cause of severe peach allergy.