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Important and specific role for basophils in acute allergic reactions
Author(s) -
Korošec P.,
Gibbs B. F.,
Rijavec M.,
Custovic A.,
Turner P. J.
Publication year - 2018
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/cea.13117
Subject(s) - anaphylaxis , degranulation , basophil , immunology , basophil activation , immunoglobulin e , effector , allergy , mast cell , medicine , asthma , allergic inflammation , receptor , antibody
Summary IgE‐mediated allergic reactions involve the activation of effector cells, predominantly through the high‐affinity IgE receptor (Fcε RI ) on mast cells and basophils. Although the mast cell is considered the major effector cell during acute allergic reactions, more recent studies indicate a potentially important and specific role for basophils and their migration which occurs rapidly upon allergen challenge in humans undergoing anaphylaxis. We review the evidence for a role of basophils in contributing to clinical symptoms of anaphylaxis and discuss the possibility that basophil trafficking during anaphylaxis might be a pathogenic (to target organs) or protective (preventing degranulation in circulation) response. Finally, we examine the potential role of basophils in asthma exacerbations. Understanding the factors that regulate basophil trafficking and activation might lead to new diagnostic and therapeutic strategies in anaphylaxis and asthma.