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Abnormal vocal cord movement in patients with and without airway obstruction and asthma symptoms
Author(s) -
Low K.,
Ruane L.,
Uddin N.,
Finlay P.,
Lau K. K.,
Hamza K.,
Holmes P. W.,
Hamilton G.,
Bardin P. G.
Publication year - 2017
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/cea.12828
Subject(s) - medicine , asthma , vocal cord dysfunction , spirometry , airway obstruction , cord , airway , larynx , pulmonary function testing , anesthesia , surgery
Summary Background Abnormal vocal cord movements can cause laryngeal extrathoracic airway obstruction (often called vocal cord dysfunction – VCD ) leading to asthma‐like symptoms. These aberrant movements are characteristically present during inspiration and termed paradoxical vocal cord movement ( PVCM ). We have reported PVCM in up to 40% of severe asthmatics, but it is not known if PVCM is detectable in all patients with asthma‐like symptoms and if the condition is more often associated with abnormal lung function. Objective We hypothesized that PVCM is frequently associated with asthma symptoms accompanied by airflow limitation. Studies examined whether PVCM is solely linked to experiencing asthma symptoms, or if PVCM is related to airflow limitation and/or other disease characteristics. Methods Patients with asthma symptoms were recruited from general practice and severe asthma clinics ( n = 155). Pulmonary function measurements were conducted, asthma control and Nijmegen (dysfunctional breathing) questionnaires were administered and skin prick testing was carried out. PVCM was quantified using dynamic 320‐slice computerized tomography of the larynx. Groups were divided into patients with FEV 1 ≥ 80% predicted or FEV 1 < 80% predicted and FEV 1 / FVC < 0.7. ATS / ERS definitions of severity were also applied and evaluated. Detection of PVCM in the groups was compared and analyses performed to identify features associated with PVCM . Results Overall ( n = 155), PVCM was detected in 42 cases (27.1%). Patients with FEV 1 < 80% predicted had PVCM more often (25/68, 36.8%) than individuals with normal spirometry (17/87, 19.5%; P = 0.016). PVCM was associated with older age ( P = 0.003) and with Nijmegen scores > 20 ( P = 0.04). Patients with FEV 1 < 80% predicted plus Nijmegen scores > 20 were more likely to have PVCM ( OR = 9.3, P = 0.02). Conclusions and Clinical Relevance Paradoxical vocal cord movement is more often associated with asthma symptoms accompanied by airflow limitation and dysfunctional breathing. Further studies are needed to determine whether PVCM is induced by dysfunctional breathing practices and/or airway obstruction. How PVCM links with symptomatic asthma and VCD also requires evaluation.