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Dendritic cells in inflammatory sinonasal diseases
Author(s) -
Cao P.P.,
Shi L.L.,
Xu K.,
Yao Y.,
Liu Z.
Publication year - 2016
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/cea.12755
Subject(s) - immunology , immune system , pathogenesis , context (archaeology) , acquired immune system , phenotype , innate immune system , inflammation , medicine , mechanism (biology) , dendritic cell , biology , paleontology , biochemistry , gene , philosophy , epistemology
Summary Dendritic cells ( DC s) are critical in linking the innate and adaptive immune responses, which have been implicated in the pathogenesis of many immune and inflammatory diseases as well as the development of tumours. The role of DC s in the pathophysiology of lung diseases has been widely studied. However, the phenotype, subset and function of DC s in upper airways under physiological or pathological conditions remain largely undefined. Allergic rhinitis ( AR ) and chronic rhinosinusitis ( CRS ) are two important upper airway diseases with a high worldwide prevalence. Aberrant innate and adaptive immune responses have been considered to play an important role in the pathogenesis of AR and CRS . To this end, understanding the function of DC s in shaping the immune responses in sinonasal mucosa is critical in exploring the pathogenic mechanisms underlying AR and CRS as well as in developing novel therapeutic strategies. This review summarizes the phenotype, subset, function and regulation of DC s in sinonasal mucosa, particularly in the setting of AR and CRS . Furthermore, this review discusses the perspectives for future research and potential clinical utility focusing on DC pathways in the context of AR and CRS .