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γδT cells regulate chronic airway inflammation and development of airway remodelling
Author(s) -
Murdoch J. R.,
Gregory L. G.,
Lloyd C. M.
Publication year - 2014
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/cea.12395
Subject(s) - inflammation , immunology , ovalbumin , medicine , airway , eosinophil , blockade , lung , immune system , asthma , receptor , surgery
Summary Background γδT cells play a crucial immunoregulatory role in the lung, maintaining normal airway tone and preventing hyperresponsiveness to innocuous allergen. During acute inflammatory episodes, γδT cells promote resolution of acute inflammation. However, their contribution to inflammation‐associated airway remodelling remains unexplored. Here we investigate the effects of γδT cell blockade on established allergic airway inflammation and development of remodelling. Methods Sensitised mice were exposed to prolonged ovalbumin challenge or continuous house‐dust mite exposure to induce chronic inflammation and remodelling. Functional blocking anti‐ TCR δ antibody was administered therapeutically, and parameters of airway inflammation and remodelling were examined. Results Therapeutic blockade of γδT cells prevented the typical resolution of acute airway inflammation characterised by elevated eosinophil and Th2 cell numbers. Moreover, the lung displayed exacerbated airway remodelling, typified by excess peribronchiolar collagen deposition. Conclusions These results demonstrate a unique role for γδT cells in constraining allergen‐induced airway remodelling. Manipulating the γδT cell compartment may therefore contribute to strategies to prevent and treat remodelling.