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Transfer of peanut IgE sensitisation after combined pancreas–kidney transplant
Author(s) -
Berry A.,
Campsen J.,
Shihab F.,
Firszt R.
Publication year - 2014
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/cea.12355
Subject(s) - medicine , immunoglobulin e , peanut allergy , sensitization , transplantation , allergy , kidney transplantation , pancreas transplantation , allergen , immunology , organ transplantation , food allergy , antibody
Summary Background The transfer of peanut allergy has been reported following solid organ transplantation. Objective Present a case of peanut sensitization following combined pancreas‐and‐kidney transplantation. Methods Circulating specific IgE against peanut were measured in serum samples collected from the transplant recipient 1 month before transplantation, and 1, 3 and 6 months after transplantation. Skin tests were performed 1, 3 and 6 months following transplant. Results The organ recipient's pre‐transplant peanut IgE levels were negative. At 1 month post‐transplant, the patient had a 6 mm skin test to peanut and had serum IgE to peanut Arah1 of 0.79 kU/L. At 3 months, skin test size and IgE to peanut Arah1 decreased to 4 mm, and 0.69 kU/L respectively. At 6 months, the patient's skin test and IgE to peanuts were negative. At that time, the patient underwent a peanut food challenge without a clinical reaction to suggest allergy. Conclusion and Clinical Relevance We report the development of IgE peanut sensitization in a recipient of a combined pancreas and kidney transplantation. Increasing awareness of this allergen sensitization following transplantation may help prevent serious allergic reactions in transplant recipients.