Premium
Ion channels regulating mast cell biology
Author(s) -
Ashmole I.,
Bradding P.
Publication year - 2013
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/cea.12043
Subject(s) - degranulation , mast cell , microbiology and biotechnology , histamine , transient receptor potential channel , ion channel , allergic inflammation , extracellular , proinflammatory cytokine , secretion , mediator , immunology , biology , chemistry , inflammation , receptor , biochemistry , endocrinology
Summary Mast cells play a central role in the pathophysiology of asthma and related allergic conditions. Mast cell activation leads to the degranulation of preformed mediators such as histamine and the secretion of newly synthesised proinflammatory mediators such as leukotrienes and cytokines. Excess release of these mediators contributes to allergic disease states. An influx of extracellular Ca 2+ is essential for mast cell mediator release. From the Ca 2+ channels that mediate this influx, to the K + , Cl − and transient receptor potential channels that set the cell membrane potential and regulate Ca 2+ influx, ion channels play a critical role in mast cell biology. In this review we provide an overview of our current knowledge of ion channel expression and function in mast cells with an emphasis on how channels interact to regulate Ca 2+ signalling.