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Cytokine regulation of the epidermal barrier
Author(s) -
GutowskaOwsiak D.,
Ogg G. S.
Publication year - 2013
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/cea.12023
Subject(s) - skin barrier , immunology , barrier function , cytokine , disease , pathogenesis , atopic dermatitis , medicine , biology , pathology , dermatology , microbiology and biotechnology
Summary Studies published in recent years have highlighted the role of epidermal barrier defects in both atopic skin disease and the development of broader allergic manifestations. While genetic determinants of barrier function are important, it is clear that local acquired effects are also involved in disease pathogenesis. In this review, we aimed to summarize the known influences of cytokines abundantly expressed during atopic skin disease on components of epidermal barrier integrity and function.