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Association between periodontitis and salivary 8‐hydroxydeoxyguanosine among Korean rural adults
Author(s) -
Shin MyungSeop,
Shin HyeSun,
Ahn YooBeen,
Kim HyunDuck
Publication year - 2016
Publication title -
community dentistry and oral epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.061
H-Index - 101
eISSN - 1600-0528
pISSN - 0301-5661
DOI - 10.1111/cdoe.12225
Subject(s) - medicine , periodontitis , odds ratio , confidence interval , logistic regression , cohort , cohort study , dentistry , chronic periodontitis , gastroenterology
Objectives This study aimed to evaluate the association between salivary 8‐hydroxydeoxyguanosine (8‐ OH dG) and periodontitis among community‐dwelling Korean adults. Methods A total of 211 adults (80 men and 131 women) were cross‐sectionally surveyed from the Sunchang Longevity Cohort. Periodontitis was defined as having at least 30% of teeth with proximal attachment loss ≥5 mm. The salivary 8‐ OH dG level was categorized into tertiles: low (<0.916 ng/ml), medium (0.916 to <2.675 ng/ml) and high (≥2.675 ng/ml). Sociodemographic, habitual and systemic health‐related factors were controlled for. Logistic regression analysis was performed for the outcome of severe periodontitis. Analysis of covariance in general linear model was performed for the outcome of 8‐ OH dG. Results The high 8‐ OH dG level showed a significant association with periodontitis. The odds ratio (95% confidence interval) was 2.40 (1.05–5.51), and it was highlighted by adding the interaction term with drinking and smoking. The adjusted mean log‐transformed value of 8‐ OH dG was significantly higher in the severe periodontitis group (1.40 ng/ml) than in the control group (1.02 ng/ml) ( ancova , P = 0.028). Conclusions 8‐ OH dG was associated with periodontitis. Thus, salivary 8‐ OH dG could be a useful marker for periodontitis.