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Fish Oil Supplementation in Pregnancy and Neurodevelopment in Childhood—A Randomized Clinical Trial
Author(s) -
Sass Laerke,
Bjarnadóttir Elín,
Stokholm Jakob,
Chawes Bo,
Vinding Rebecca K.,
MoraJensen AnnaRosa C.,
Thorsen Jonathan,
Noergaard Sarah,
Ebdrup Bjørn H.,
Jepsen Jens R.M.,
Fagerlund Birgitte,
Bønnelykke Klaus,
Lauritzen Lotte,
Bisgaard Hans
Publication year - 2021
Publication title -
child development
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.103
H-Index - 257
eISSN - 1467-8624
pISSN - 0009-3920
DOI - 10.1111/cdev.13541
Subject(s) - pregnancy , gross motor skill , randomized controlled trial , child development , psychology , cognitive development , offspring , early childhood , motor skill , developmental milestone , pediatrics , language development , placebo , cognition , developmental psychology , medicine , psychiatry , alternative medicine , pathology , genetics , biology
A double‐blind randomized controlled trial of n‐3 long‐chain polyunsaturated fatty acid (n‐3 LCPUFA) supplementation or matching placebo during third trimester of pregnancy was conducted within the COPSAC 2010 mother‐child cohort consisting of 736 women and their children. The objective was to determine if maternal n‐3 LCPUFA pregnancy supplementation affects offspring neurodevelopment until 6 years. Neurodevelopment was evaluated in 654 children assessing age of motor milestone achievement, language development, cognitive development, general neurodevelopment, and emotional and behavioral problems. Maternal n‐3 LCPUFA supplementation during pregnancy improved early language development and reduced the impact of emotional and behavioral problems. The n‐3 LCPUFA supplementation was in boys associated with the earlier achievement of gross motor milestones, improved cognitive development, and a reduced impact of emotional and behavioral problems.