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Assessment of Autism Symptoms From 6 to 18 Months of Age Using the Autism Observation Scale for Infants in a Prospective High‐Risk Cohort
Author(s) -
Zwaigenbaum Lonnie,
Bryson Susan E.,
Brian Jessica,
Smith Isabel M.,
Sacrey Lori,
Armstrong Vickie,
Roberts Wendy,
Szatmari Peter,
Garon Nancy,
Vaillancourt Tracy,
Roncadin Caroline
Publication year - 2020
Publication title -
child development
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.103
H-Index - 257
eISSN - 1467-8624
pISSN - 0009-3920
DOI - 10.1111/cdev.13485
Subject(s) - autism , autism spectrum disorder , psychology , cohort , pediatrics , prospective cohort study , medical diagnosis , pervasive developmental disorder , clinical psychology , audiology , developmental psychology , medicine , pathology
The objectives were to characterize behavioral signs of autism spectrum disorder (ASD) in younger siblings of diagnosed children (high‐risk; HR) and examine classification features of the Autism Observation Scale for Infants (AOSI). Participants (501 HR and 180 low‐risk [LR]) were assessed between 6 and 18 months using the AOSI and at age 3 for ASD diagnoses. Total AOSI scores differentiated HR infants later diagnosed with ASD starting at 12 months. ROC analyses identified 12‐ and 18‐month cutoff scores associated with 0.52 sensitivity and 0.74 specificity and 0.73 sensitivity and 0.65 specificity, respectively. Although classification accuracy does not support use as a standalone screen, the AOSI identifies features associated with ASD starting at 6 months and differentiates HR infants with ASD by 12 months.