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The Contributions of Maternal Sensitivity and Maternal Depressive Symptoms to Epigenetic Processes and Neuroendocrine Functioning
Author(s) -
Conradt Elisabeth,
Hawes Katheleen,
Guerin Dylan,
Armstrong David A.,
Marsit Carmen J.,
Tronick Edward,
Lester Barry M.
Publication year - 2016
Publication title -
child development
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.103
H-Index - 257
eISSN - 1467-8624
pISSN - 0009-3920
DOI - 10.1111/cdev.12483
Subject(s) - dna methylation , depressive symptoms , psychology , maternal sensitivity , epigenetics , saliva , depression (economics) , clinical psychology , glucocorticoid , developmental psychology , medicine , psychiatry , anxiety , genetics , gene , biology , gene expression , macroeconomics , economics
This study tested whether maternal responsiveness may buffer the child to the effects of maternal depressive symptoms on DNA methylation of NR3C1 , 11 β ‐HSD2 , and neuroendocrine functioning. DNA was derived from buccal epithelial cells and prestress cortisol was obtained from the saliva of 128 infants. Mothers with depressive symptoms who were more responsive and who engaged in more appropriate touch during face‐to‐face play had infants with less DNA methylation of NR3C1 and 11 β ‐HSD2 compared to mothers with depressive symptoms who were also insensitive. The combination of exposure to maternal depressive symptoms and maternal sensitivity was related to the highest prestress cortisol levels, whereas exposure to maternal depressive symptoms and maternal insensitivity was related to the lowest prestress cortisol levels.