Caregiving and  5‐HTTLPR  Genotype Predict Adolescent Physiological Stress Reactivity: Confirmatory Tests of Gene × Environment Interactions | Zendy

Sumner Jennifer A. | Zendy; McLaughlin Katie A. | Zendy; Walsh Kate | Zendy; Sheridan Margaret A. | Zendy; Koenen Karestan C. | Zendy

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Caregiving and 5‐HTTLPR Genotype Predict Adolescent Physiological Stress Reactivity: Confirmatory Tests of Gene × Environment Interactions

Author(s) -

Sumner Jennifer A.,

McLaughlin Katie A.,

Walsh Kate,

Sheridan Margaret A.,

Koenen Karestan C.

Publication year - 2015

Publication title -

child development

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.103

H-Index - 257

eISSN - 1467-8624

pISSN - 0009-3920

DOI - 10.1111/cdev.12357

Subject(s) - psychology , diathesis , 5 httlpr , diathesis–stress model , developmental psychology , genotype , allele , confirmatory factor analysis , clinical psychology , reactivity (psychology) , serotonin transporter , structural equation modeling , genetics , gene , immunology , medicine , statistics , mathematics , medical tourism , tourism , biology , political science , law , alternative medicine , pathology

A theory‐driven confirmatory approach comparing diathesis–stress and differential susceptibility models of Gene × Environment (G × E) interactions was applied to examine whether 5‐HTTLPR genotype moderated the effect of early maternal caregiving on autonomic nervous system ( ANS ) stress reactivity in 113 adolescents aged 13–17 years. Findings supported a differential susceptibility, rather than diathesis–stress, framework. Carriers of one or more 5‐HTTLPR short alleles ( SS / SL carriers) reporting higher quality caregiving exhibited approach ANS responses to a speech task, whereas those reporting lower quality caregiving exhibited withdrawal ANS responses. Carriers of two 5‐HTTLPR long alleles ( LL carriers) were unaffected by caregiving. Findings suggest that 5‐HTTLPR genotype and early caregiving in interaction are associated with ANS stress reactivity in adolescents in a “for better and for worse” fashion, and they demonstrate the promise of confirmatory methods for testing G × E interactions.

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