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Why Do Only Some Institutionalized Children Become Indiscriminately Friendly? Insights From the Study of Williams Syndrome
Author(s) -
Soares Isabel,
Belsky Jay,
Mesquita Ana R.,
Osório Ana,
Sampaio Adriana
Publication year - 2013
Publication title -
child development perspectives
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3
H-Index - 71
eISSN - 1750-8606
pISSN - 1750-8592
DOI - 10.1111/cdep.12036
Subject(s) - endophenotype , psychology , developmental psychology , neuropsychology , phenotype , cognition , gene , neuroscience , genetics , biology
Why do some institutionalized children develop indiscriminate behavior ( IB ) while others do not? Considering children with W illiams syndrome (WS) may provide an answer because IB has been observed routinely among individuals with this rare genetic neurodevelopmental disorder. By conceiving WS as a natural genetic model that mimics the indiscriminate phenotype and, more importantly, is associated with the deletion of genes in a specific region, we propose an integrative conceptual framework that underscores the dynamic developmental interplay between genes, endophenotypes, and environment. In this article, we consider the etiology of IB among institutionalized children, which emphasizes environmental factors, followed by the effect of such behavior on WS children's hypersociability, which highlights the crosstalk between genes and neuropsychological features in programming their distinctive social‐emotional and behavioral phenotype. We propose new hypotheses regarding the etiopathogeny of IB s in institutionalized children, particularly the prediction of specific Gene × Environment interactions.