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1,3,4‐oxadiazole and its derivatives: A review on recent progress in anticancer activities
Author(s) -
Vaidya Ankur,
Pathak Devender,
Shah Kamal
Publication year - 2021
Publication title -
chemical biology and drug design
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.59
H-Index - 77
eISSN - 1747-0285
pISSN - 1747-0277
DOI - 10.1111/cbdd.13795
Subject(s) - oxadiazole , chemistry , anticancer drug , combinatorial chemistry , mechanism of action , drug discovery , drug , computational biology , pharmacology , biochemistry , biology , organic chemistry , in vitro
The 1,3,4‐oxadiazole nucleus is a biologically imperative scaffold possesses numerous biological activities. The broad and potent activity of 1,3,4‐oxadiazole and their derivatives has established them as important pharmacological scaffolds especially in the treatment of cancer disease. Several di‐, tri‐, aromatic, and heterocyclic substituted 1,3,4‐oxadiazole derivatives have been reported to possess potent anticancer activity. These substituted 1,3,4‐oxadiazoles had shown different mechanism of action and participated in anticancer drug discovery and development. This review is complementary to earlier reviews and aims to review the work reported on anticancer activities of 1,3,4‐oxadiazole derivatives from year 2000 to the beginning of 2020.